The singer picked up two of the main prizes - song of the year, for Hello, and album of the year, for 25.
"I'm so sorry I'm not there," she said in a message from Los Angeles. "It's been a long year on the road and this makes me feel a little less homesick."
Last year, the star won best British artist and best live performance. Again she was unable to attend.Adele performs at Glastonbury. Photo: BBC
Coldplay were another absent winner at this year's ceremony, accepting their prize for Best British artist as they walked on stage in Australia.
"Sorry we're not there," said Chris Martin, in a video message from Melbourne's Etihad Stadium. "Look at all those people - and we love you and we're so grateful and we'll see you so soon."
Media captionThe 1975 open the BBC Music Awards with The Sound.
Media captionJohn Legend performs All Of Me and Love Me Now
Now in their third year, the BBC Music Awards aim to replicate the success of the BBC's Sports Personality of the Year, recognising achievement in music both in the UK and abroad.
BBC Music editor James Stirling said that rewarding artists who were not able to attend proved the show's legitimacy.
"The BBC Music Awards have never been about who's here on the night gets a prize. It shows a degree of legitimacy to what we do.
"Adele's on holiday. There's nothing we can do about that. But it actually shows that the awards are all about people who really deserve to win."
(BBC)