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Vibrant Chelsea made it a torrid few days for Liverpool as goals by their Brazilian forward Willian and English midfielder Ross Barkley sealed a 2-0 victory to send them through to the Football Association (FA) Cup quarterfinals on Tuesday.

Liverpool's 44-match unbeaten streak in the Premier League ended in stunning fashion with a 3-0 defeat at Watford on Saturday and they were rocked again at Stamford Bridge.

Keeper Adrian, in for the rested Alisson, endured a horrible moment when he allowed Willian's powerful shot to bounce off him and into the net in 13th minute.

To complete a miserable night for Liverpool, former Everton midfielder Barkley drove home Chelsea's second goal just past the hour mark after a surging run.

English midfielder Ross Barkley (C) celebrates with teammates after scoring a goal in the 64 minute to seal Chelsea's 2-0 win over Liverpool in the FA Cup in London, March 3, 2020. /VCG

Eight-time winners Chelsea thoroughly deserved their win and manager Frank Lampard will take heart from the fact that on the last two occasions they have beaten Liverpool in the Cup they have gone on to lift the trophy.

"They are the best team in the land; this year what they are doing in the league is incredible," Lampard said.

"So for us to put in the effort, focus, determination and quality was something special tonight. It's a one-off I know, but you have to celebrate these moments."

After having their dream of an unbeaten season wrecked at Watford, Liverpool's manager Jurgen Klopp made seven changes but still started with Virgil van Dijk, Sadio Mane, Joe Gomez, Andy Robertson and Fabinho – a far cry from the previous round at Shrewsbury when he fielded a virtual under-21 side.

Liverpool's Divock Origi #27 sees his shot saved by Chelsea's Kepa Arrizabalaga int the FA Cup in London, March 3, 2020. /VCG

It was clear from the start that Klopp wanted an immediate response to the Watford shocker, and he almost got it with Mane failing to capitalize on a golden early chance.

For Liverpool, a season of utter dominance which will almost certainly deliver a first league title for 30 years, has suddenly hit the buffers.

"We deserved to lose because they scored twice and we made massive mistakes for both goals," Klopp said.

"Nobody has to feel sorry for us, we will win football games and that is what we want to do on Saturday."

Newcastle United's Miguel Almiron (R) scores a goal during an FA Cup match against West Bromwich Albion in West Bromwich, UK, March 3, 2020. /VCG

Also on Tuesday, Paraguayan midfielder Miguel Almiron struck twice as Newcastle United reached the FA Cup quarterfinals for the first time since 2006 with a 3-2 win at second-tier West Bromwich Albion.

Sheffield United joined the Magpies in the last eight but needed extra time to see off Reading 2-1.