Asian markets turned negative again on Monday as the fallout from Donald Trump's steel and aluminium tariffs continues to feed concerns of a global trade war.
Equities went into a tailspin last week after the tycoon unveiled his plans for the controversial levies, and while US investors ended Friday on a slightly positive note, there is still the prospect of more volatility to come.
Trump ramped up his rhetoric at the weekend, tweeting that "Our friends and enemies have taken advantage of the US for many years", before adding "Sorry, it's time for a change!"
The move, part of the president's "American First" protectionist drive, was met with fury across the world with officials from Beijing to Brussels raising concerns.
"Uncertainty has lifted materially, folks, as countries react to the tariffs and a trade war and retaliatory measures loom as a real possibility unless President Trump finds a way to step back," said Greg McKenna, chief market strategist at AxiTrader.
Hong Kong led losses, falling more than one percent, while Tokyo finished the morning session 0.7 percent lower.
Shanghai shed 0.2 percent, with eyes on the start of China's annual rubber-stamp parliament, which kicked off its most significant meeting in a generation, preparing to offer Xi Jinping a lifetime mandate to rule the world's number two economy.
Chinese Premier Li Keqiang set a target of "around 6.5 percent" economic growth for the world's number two economy this year
Premier Li Keqiang set a 2018 economic growth target at "around 6.5 percent", in line with expectations but lower than the 6.9 percent increase registered last year.
Sydney and Seoul each slipped 0.5 percent while Singapore was off 0.6 percent and Manila gave up 0.8 percent.
The dollar came under further pressure on worries about a trade war, with the safe haven yen extending last week's gains, helped by comments from the head of the Bank of Japan last week suggesting crisis-era stimulus could be scaled back from next year.
Stephen Innes, head of Asia-Pacific trading at OANDA, said: "Trump is carrying the seeds of the dollar's destruction.
"The economic fallout from trade duties would result in a toxic elixir of lower domestic growth and higher inflation, neither of which inspires investors confidence in the dollar."
The euro also got support from news that German Chancellor Angela Merkel would form a new government, ending months of uncertainty in Europe's biggest economy, though Italy was on course for a hung parliament after a weekend general election.
Key figures around 0230 GMT
Tokyo - Nikkei 225: DOWN 0.7 percent at 21,043.61 (break)
Hong Kong - Hang Seng: DOWN 1.2 percent at 30,231.19
Shanghai - Composite: DOWN 0.2 percent at 3,248.59
Euro/dollar: UP at $1.2332 from $1.2300 at 2200 GMT on Friday
Pound/dollar: UP at $1.3800 from $1.3792
Dollar/yen: DOWN at 105.54 yen from 105.73 yen
Oil - West Texas Intermediate: UP 40 cents at $61.65 per barrel
Oil - Brent North Sea: UP 42 cents at $64.79 per barrel
New York - DOW: DOWN 0.3 percent at 24,538.06 (close)
London - FTSE 100: DOWN 1.5 percent at 7,069.90 (close)